11

Sep

Develop a micro LED array ultra -thin film: Irradiate light for a specific part of the brain

Toyohashi Technical Science, Dokkyo Medical University, and Okinawa Science and Technology Graduate University have announced in March 2022 that they have developed a “multi -point micro LED array ultra -thin film” for light, light and flexible optical genes.Expect to apply to new neurological research.

In recent years, in recent years, the “vocabetic biography method” has been used in recent years, which allows light from the outside of the living body to control the activity of nerve cells.What is needed here is a device for the vocabulary that can simultaneously irradiate light to specific parts and multiple parts of the brain.However, the current LEDs were large and thick, so it was difficult to create devices that cover the brain in a wide range.

光遺伝学用マイクロLEDアレイ極薄フィルムを開発:脳の特定部位を狙って光を照射

Therefore, the research group decided to place a multi -point micro LED with a LED size of 100 μm or less and a thickness of several μm.For this reason, "micro LED hollow structure formation technology" and "micro LED array batch transfer technology" were developed.

上図はマイクロLED中空構造の形成技術、下図はマイクロLEDアレイ一括転写技術 出所:豊橋技術科学大学他左図はマイクロLEDアレイ中空構造、右図はマイクロLEDアレイ極薄フィルムの発光像 出所:豊橋技術科学大学他

Here are these manufacturing methods.First, an anisotropic wet etching method by potassium hydroxide solution is applied, and the lower part of the LED layer is selectively removed.As a result, a high -density arranged micro LED hollow structure was formed.Since the LED layer was separated from the board and the LED layer was separated from the substrate, only the LED layer was removed in a lump.

マウス脳に密着したマイクロLEDアレイ極薄フィルムと、3カ所のLEDを点灯させた光照射の様子 出所:豊橋技術科学大学他

These steps have arranged a micro LED on the paralleleen film, a biometric film.The micro LED film produced does not deteriorate the light irradiation characteristics even when bent, and it has been found that even in the optical gene experiment using a mouse, a bright blue light emission that controls brain activity is obtained.

The results of this research are Hiroto Sekiguchi of Toyohashi Technology University of Technology and Electronic Information Engineering, Associate Professor Yoshiaki Okawa, a Dokkyo Medical University Integrated Medical Sciences, and a neuroscience unit of Okinawa Science and Technology University's Semorable and Action.It is by Associate Professor Izumi Fukunaga.