Discover the material of the stuffy nose with the mouse!Expectations for the development of groundbreaking treatment

Discover the material of the stuffy nose with the mouse!

The stuffy nose is an unpleasant symptom that everyone experiences.

Among them, allergic rhinitis such as hay fever is extremely common, and the nasal mucosa is inflamed, the body fluids are oozed out of the blood vessels, the mucous membrane is swollen, and the inflow of air is hindered.

Histamine is well known as such a material that causes such inflammation.

For this reason, the existing nasal accumulation of nasal accumulation is used for blood vessels in the mucous membrane (nasal drugs) and antihistamines that remove swelling and remove swelling.

However, the decisive causative substances that cause stuffy nose have not been revealed.

Nasal drops and antihistamines certainly have the effect of suppressing stuffy nose, but both are drugs for suppressing inflammation and eliminating the swelling of the mucous membrane, and does not deal with the source of the stuffy nose.

As a result, there are opinions that if the stuffy nose is resolved, it is said that it is okay, but nasal drops and antihistamines have a wide range of effects, so if you continue to use it for a long time, it will be more than the same effect.You will need the medicine.

On the other hand, if you can find and control the causative substance that is a direct trigger of stuffy nose, you may be able to provide more effective treatment.

The nostrils were always worse on one air

This time, researchers at the University of Tokyo forcibly recovered the "mouse runny nose (nasal cleaning solution)", which was forced to have allergic rhinitis, and examined the substances produced in the nasal mucosal of the mouse that had rhinitis.

As a result, it has been found that a kind of lipid called "15-Hydroxy Eicosadienoic Acid) exists at higher concentrations than known inflammatory substances (prostaglandin).

So the researchers, on the contrary, extracted only 15-Hide and added them to the nasal cavity of the mouse.

Then, it is indicated that the mouse causes stuffy nose and has difficulty breathing.

Also, when 15-Hede was administered to the mouse vein, the blood vessels relaxed and promoted blood flow, and when administered to the ears, it was possible to see that bodily fluids were being packed out.

This shows the possibility that 15-Hede is the cause of the mouse stuffy nose.

Researchers have stated that if the production of 15-Hede could be reduced, it could be a groundbreaking drug.